Monday, October 19, 2020

Perspectives on Immunity: Sharon Weizenbaum & Shang Han Lun Theory

As I write this, we are deep into autumn and winter is coming. It’s the time of year when many of us start to think more about how well our immune system is functioning. We hope to be able to avoid more severe courses of the seasonal viruses that will inevitably circulate during the winter months. This year, of course, we not only have colds and influenza to worry about. We continue to be preoccupied with COVID-19, which appears to be surging around the world with the coming of winter to the northern hemisphere. Those of us in the Western United States may wonder, additionally, whether persistent exposure to wildfire smoke (or avoidance of outdoor activity due to smoky air) over the past two months, during this year’s unprecedented fire season, may have impacted our abilities to deal with infections this winter.




In this late autumn context, in the midst of a pandemic, with flu season up on us, I thought it could be useful to talk about immunity.

I’ve been thinking a lot about immunity this year and gotten some interesting perspectives from various teachers of herbal medicine. If time allows, I'd love to present some of these views in upcoming blogposts.

I'll start today with a teaching on immunity that I heard from Sharon Weizenbaum, a long-time herbalist and acupuncturist based in Amherst, Massachusetts, where she directs the White Pine Institute. Dr. Weizenbaum is a scholar of Chinese language and classical Chinese herbalism. She and her students have been leading voices in the discussion of Chinese herbal approaches to COVID-19 in the United States.

In March 2020, as the pandemic arrived in North America, Dr. Weizenbaum and her colleagues were learning about the treatment of COVID-19 in China & beginning to treat COVID patients on the East Coast, using classical Chinese herbal medicine prescriptions. At that time, Dr. Weizenbaum gave a lecture on her interpretation of the Chinese medicine perspective on immunity and the immune system, drawing particularly on the classical Chinese Medicine text, the Discussion of Cold-Induced Disorders, or Shang Han Lun, attributed to the Eastern Han Dynasty physician Zhang Zhong-jing (150-219 CE.)


This lecture was much more theoretical than practical, and did not go into specific herbs and therapies. I found interesting Dr. Weizenbaum's effort to "open the narrative" on immunity, distinguishing between an us-vs-them perspective & a more holistic, integrated view of host and environment.



Opening the “Standard Narrative” on Immunity:


Dr. Weizenbuam begins her lecture by stating that there is a standard narrative on immunity that informs our approach to infectious disease in the modern, western world. It is characterized by a dualistic and militaristic quality, an "us vs them" perspective. It is basically:


  • There are bad things out there. They can “get in” and “GET ME.”

  • The way to stay healthy is to strengthen my defenses and keep the bad things OUT.

  • If they get in, I need to ATTACK them, kill them, and/or get them out.

  • My “immune system” keeps things out and helps my body FIGHT BAD THINGS OFF.


Dr. Weizenbaum acknowledges the value of this narrative for some purposes. In the context of the pandemic, the narrative of “there are bad things out there that can get inside of me” forces us to social distance, which in turn slows the spread of the virus and saves lives


At the same time, Dr. Weizenbaum states that this narrative of immunity can have some negative outcomes. She seeks to open our understanding of immunity to different narratives.



There is No “One-Size-Fits-All” Approach,

Everyone Needs to be Treated as an Individual:


Dr. Weizenbaum acknowledges that the idea that “there are bad things out there that can get inside of us” created an atmosphere of fear at the onset of the pandemic. Some of us sought protective herbs. Various one-size-fits-all preventive herbal or medicinal formulations got pedaled around the internet. There were recommendations for herbal formulas consisting of cold, bitter “antiviral” herbs; and others for warm, dispersing “protective” herbs. Dr. Weizenbaum points out that herbal prescribing needs to be more nuanced, based on a complex understanding of the natures and qualities of herbs, as well as the synergistic qualities of herbal formulations. It also needs to be based on an understanding of each individual’s specific need as determined by a differential diagnosis of symptom patterns and constitution. If a patient is already cold, they should not take cold, bitter herbs. This could make them worse. If a patient is symptomatic, they should probably not take warming, tonifying herbs. Simplistic one-size-fits-all herbal preventive measures, though attractive in the face of a scary viral pandemic, could be dangerous for certain individuals. 



The Immune System is Not Just One Thing:


Dr. Weizenbaum continues her lecture by broadening our perspective on the immune system. Asking, “How, then, do I help my immune system?”, she notes:


  • The “immune system” is none other than the sum-total of the functions of my whole body. Immunity is based on the collective functioning of all body systems: circulatory, digestive, respiratory, nervous, etc.

  • If this is true, I should observe: How does my body function? How is my body not functioning optimally? 

  • Often one can observe a weak link or two in how our body is functioning. This weak link, she states, is the area that needs strengthening, or optimizing, as we seek to improve our immunity.


For example, if every time I eat, I get bloated, and food moves through my body really slowly, perhaps this inhibits my body’s ability to create healthy cells. So, digestion and assimilation of nutrients is the area that needs attention as I seek to boost my immunity.

Or, if I have asthma and don’t breathe well, then that’s an important area to address, in relation to protecting myself against the virus.

Or if my sleep is poor and I experience excessive stress, then I might address that issue at its root.


Various Historical Approaches to Infectious Disease in Chinese Medicine:


Next in her lecture, Dr. Weizenbaum briefly surveys some of the approaches to infectious disease in various historical periods of the Chinese medicine traditions.  You can find a brief summary of these here, in one of my blog posts from earlier this year.


Dr. Weizenbaum concludes that some of these approaches are still dominated by the narrative of “bad things out there.” For example, she states, the 18th century “Wen Bing” or “Warm Disease” theory, which arose in China in response to the introduction of western viral infections like measles & mumps, is basically restatement of the idea that there are “bad” viral pathogens out there that can get inside of me. In the Wen Bing school of thought, we look at a patient’s symptoms to reveal the “nature of the pathogen.” I.e., if the patient’s tongue has a yellow-greasy coating, then the pathogen must be warm and damp. But what exactly does this mean, that the pathogen is warm-damp? Is there really a pathogen inside of us spreading heat and dampness? What exactly is that pathogen doing in our body? Modern-day practice of Traditional Chinese Medicine continues to follow this pathogen-focused approach: i.e. we have to find, identify and attack the pathogen, using herbs that counter the nature of that pathogen. With the increased influence of western biomedical theory, modern practitioners of TCM seek to add herbs shown to have “antiviral” properties to our armory for treatment and prevention of viral infection.

 

Ultimately, having surveyed these historical Chinese medical schools and trends, Dr. Weizenbaum chooses to be guided by the older classical Shang Han Lun (or Cold-Induced Disorder) laid out in the writings of the Eastern Han Dynasty Physician Zhang Zhong-Jing (150-219 CE,) which she feels is more compatible with an expanded understanding of the human immune system. Again, see my previous blog post for more information on these various historical streams in the Chinese medicine approach to infectious disease.


Eastern Han Dynasty Physician Zhang Zhong-Jing


“This is a Narrative About the World and Life:” A Different Narrative on Immunity


In her understanding of Shang Han Lun theory of diagnosis and herbal treatment, Dr. Weizenbaum sees an understanding of immunity that is wider than the dualistic, militaristic “bad things out there that I need to protect myself against” narrative.


The narrative she seeks to embrace, in her approach to health, healing and immunity, is about the world and life. It involves an understanding that:


  • The nature of life is one of interconnection;

  • Health is about being in a workable relationship with life;

  • Healing is about coming into this workable relationship with life.


The fact is that the novel coronavirus (COVID-19) has become a part of our world. Part of “boosting our immunity” to this virus might be our body making a shift so that we can eventually live with the virus without it causing us problems. Illness or infection with the virus might be perceived as a process of our body shifting, so that we can now live with the virus as part of our world.


Dr. Weizenbaum states that, with this shift in perspective, the question changes from “how do I keep the virus out of me?” (although this is also important at this stage!) to “When I do get sick, how can I help my body process this, so it doesn't hurt me so much? How can I improve my chances of coming through the illness well, and to become able to live with the virus being part of my world?”


Dr. Weizenbaum states that Chinese medicine, and Chinese herbs, have a lot to offer in terms of helping our bodies shift into a workable relationship with the new virus.



What Is COVID-19 then? And how does it relate to our Immune System?


Dr. Weizenbaum states that COVID-19 is something new in our world that we are being forced to come into relationship with. And our immune system, in this narrative, is the sum of all our body functions that help us learn to come into relationship with the outside world. It is our immune system that enables us to learn to live in harmony with the world outside our bodies, which now includes the COVID-19 virus. This view is in contrast to the dualistic, militaristic idea of our immune system “fighting off the virus.”



How Do the Symptoms of COVID-19 Guide Us?


Dr. Weizenbaum tells us that our symptoms, when we contract an illness, tell us two things:


  1. The specific ways in which our specific body is having a hard time coming into relationship with this illness, and

  2. What demands this new illness is making is making on our individual body as we come into relationship with it. (i.e. we can consider what particular demands this particular virus is making on certain systems of our individual bodies, based on where dysfunction shows up as we encounter the virus.)



As A Healer…


As healers, then, our goal is to help the patient’s body come into relationship with this new virus. (The same can be said for any of us caring for ourselves as we encounter a new challenge.) Our process of diagnosis is to observe where the body is having a hard time in terms of physiological functions (rather than considering the specific nature of the pathogen.) Our treatment is to provide measures to help the body process this new challenge better, and to not let it kill us/the patient.



Seeing the Body as a Circle


Having established a foundational framework that our bodies are part of an interconnected network of life in the world, Dr. Weizenbaum further describes how our bodies relate to and interact with the world. Our bodies, she states, function as a circle. We are constantly taking in life and nature, and giving back to nature. In this way, we live with nature. We are nature.


We take in life/nature in a vertical downward motion, according to natural rhythms, through breath, digestion, our pores, our senses and our hearts. We give back to nature not only through our breath, our pores, our excrement, but also through our actions, our relationships, our creations, our lives.


If we try to keep something out (as in “keep out the virus,”) we are stopping a natural, cyclical process.


So, we are constantly taking in and giving back, in a cyclical manner. We are in a permeable relationship with life. The ability to do this well is the mark of a healthy immune system.


Problems (illness) occur when:


  • Our body doesn’t process something well, or

  • Something is being demanded of our body that is beyond our body’s ability to process. 


By extension, COVID-19 makes a person very ill or, tragically, kills a person when:

  • The person’s body can’t process the virus in some way, and 
  • The person’s body does not get the help it needs to process the illness. 

At least in the early stages of the pandemic, western medicine was mostly at a loss in terms of what to offer to help a patient's body process the virus before it became severe or life-threatening. Some interventions might include a humidifier, or over-the-counter medications like robitussin or mucinex. Chinese herbs are another supportive intervention.

COVID-19, Dr. Weizenbaum states, is coming into our world with very particular demands on our bodies. Her application of herbs is to help the body shift in a way to allow the novel virus to move through without hurting us so much. Diagnosis is identifying where in the cyclical process of taking in nature and giving back our bodies need help. The signs and symptoms an individual experiences in the course of a COVID infections give us the answer: where exactly in this cycle does the body need help to process.


I will not go deeply into Shang Han Lun theory here, because that's a more lengthy & complicated discussion. Suffice it to say, Shang Han Lun theory illustrates six places in this this circular cycle where obstruction, insufficiency or dysfunction can occur. (For example, is there a blockage in our body's ability to vent a pathogen at early onset? Is there a blockage in the descension of food and oxygen? Do we lack ability store vital energy? Is our ability to tranform what comes in into vital energy? Etx.) Signs and symptoms are very specifically described in the Shang Han Lun text, which guide diagnosis of these dysfunctions. Herbal formulas aid physiological function by addressing these specific areas of dysfunction.


In conclusion, I thought that this holistic perspective on immunity provides a nice counterpoint to our dominant narrative on host vs pathogen. I see these contending narratives play out in various medical approaches. On one extreme, western medicine devotes itself to understanding the nature of the infectious pathogen and its impact on our bodies in minute biochemical detail, and thereby learning how to fight and kill it. Holistic medicine, by contrast, tends to be more interested in cultivating the host's immune physiology. May the two systems work together, and perhaps the holistic view perspective might help us live in the world with less fear, and more peace and gentleness.





Half a Year into the COVID-19 Pandemic: Some Updates on COVID Research, Thoughts on Collective & Social Immunity, the Epidemic of Fear concept, etc.

As I write this, we are deep into autumn and winter is coming. It’s the time of year when many of us start to think more about how well our immune system is functioning. We hope to be able to avoid more severe courses of the seasonal viruses that will inevitably circulate during the winter months. This year, of course, we not only have colds and influenza to worry about. We continue to be preoccupied with COVID-19. Those of us in the Western United States may wonder, additionally, whether persistent exposure to wildfire smoke (or avoidance of outdoor activity due to smoky air) over the past two months, during this year’s unprecedented fire season, may have impacted our abilities to deal with infections this winter.





I thought I'd take some time to write out some of my musings on the pandemic, having watched in unfold in Berkeley during the past six months:



Western Medical Research & COVID:  A Round-Up of Recent News Articles:

In its approach to COVID-19, the western medical establishment has devoted itself to understanding everything it can about the COVID-19 virus and its transmission at a biochemical level. In the course of treating severely ill COVID patients, researchers and medical professionals are learning more about which medical treatments work and which don’t. Remdesivir, dexamethasone, and monoclonal antibodies all seem to offer some help to COVID patients. Here are a few related news items from the last couple of weeks: 


Here’s an interesting article on emerging evidence of the efficacy of monoclonal antibody treatment in combating COVID-19. Monoclonal antibodies was one of the treatments President Trump received in hospital after contracting the virus.


It seems the jury is still out on the effectiveness of remdesivir, a broad-spectrum antiviral medication which showed promise in the treatment of lower respiratory tract infections related to COVID-19. One study published in the New England Journal of Medicine on Oct 8, 2020, concluded that remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with COVID-19 and having evidence of lower respiratory tract infection. On the other hand, a preliminary report, released a week later, of the World Health Organization (WHO)’s large scale “Solidarity Clinical Trial” for COVID-19 treatments, suggested that remdesivir had no substantial effect on COVID-19 patients’ mortality. 


Public health officials continue to do their best to recommend measures, like masks, social-distancing and handwashing, for slowing the spread. It seems that the ultimate goal of the medical establishment, in its approach to the virus, is the production and dissemination of an effective vaccine. However, it’s unclear how quickly we might really be able to return to “normal life” even after the approval and dissemination of a vaccine, as this interesting New York Times article points out.


Finally, if you need a dose of cautious COVID-related optimism, here's a interview with New York Times Science & Health Reporter Donald McNeil, recorded in the context of the current autumn surge.



How Much Does Western Medicine Consider the Immune System?

Practitioners of holistic/alternative systems of medicine are often quick to point out that, in its search to understand the COVID-19 virus and develop a medical cure and a vaccine, the western medical establishment directs little attention at the body’s innate capacity to resist infection, or to its capacity to successfully fight off the viral infection if a patient is unfortunate enough to contract the virus. That is, the western medical establishment tends to pay a lot less attention to the immune system of the human host in comparison to nature of the pathogen.



What About Our “Collective Immunity” as a Society? Or “Economic Immunity”?

The question of social vulnerability, fortunately, is receiving somewhat more attention from social scientists, public health researchers and journalists. Why have some segments of our society, namely Black, Latino, Native and poor and front-line worker communities, been so disproportionately affected by COVID in comparison to White & affluent folks? At this point, in late 2020, evidence also is also emerging that non-COVID-related death rates among people of color have also increased disproportionately, in relation to white or to total population, this year. You don’t have to search far for analyses of these trends: Here’s one article from Brookings. Here’s another from NPR.


Why has the pandemic had such a devastating effect on our economic systems, with some segments of the economy and workers being much more hard-hit than others?


In addition to taking a holistic approach to augmenting the immunity of our individual bodies, might we not begin to think about a truly inclusive “social immunity,” as we recover and rebuild after this pandemic? Will we institute programs to promote more broad-based economic resilience?



Should We “Fear” the Virus?

President Donald Trump emerged from his own infection with the COVID-19 virus saying, essentially: Don’t fear the virus. It’s no big deal. It’s not worse than the seasonal flu. “Don’t let it disrupt your life.”


Now, I’m going to assume most people reading this will see this merely as part of the ongoing stream of irresponsible, callous and narcissistic gestures that masquerade as leadership from this administration. It is regrettable that this president, who was flown to Walter Reed Hospital in a private helicopter and received every available cutting edge medical therapy, failed to express empathy for the thousands of families who have suffered & lost loved ones to COVID, none of whom had access to the health care services that he did. It is also regrettable that he perpetuated a narrative of toughness and machismo, based on lies and mistruths.



An Epidemic of Fear?

Interestingly, during these pandemic months, I have also occasionally heard this line: “Don’t fear the virus,” coming from some folks of the holistic/alternative health community. Some segments of the holistic health community have tended to downplay concerns about COVID-19, saying something like, “What we are really facing is an epidemic of fear.” We shouldn’t let fear control us.  We should understand that, if we tend to our individual health, our immune systems can be strong enough, tough enough, to “handle” this virus.


On one hand, I resonate with the spirit of this assertion. There truly is a lot we can do to improve our bodies’ capacities to fight off, or process, viral infection (from exercise, to sleep and rest, to eating good foods, to spending time outdoors, to getting acupuncture treatments, to using herbal medicine to fine-tune our body’s physiological function, etc.) See, for example, my article from March 2020, Staying Healthy (and Sane) During the Pandemic. Also, I can acknowledge the subtle & not-so-subtle effects of daily anxiety about the virus in myself and my family, like how hard & scary it becomes to leave the house, and how unnatural human contact feels, after sheltering in place for several weeks at a time.


On the other hand, I feel uncomfortable with this “epidemic of fear” rhetoric. Taken to an extreme, it can make people feel embarrassed and ashamed about taking precautions that are actually life-saveing, like wearing masks, social-distancing, etc. We are not all equally equipped to “handle” this virus. Some of us have pre-existing conditions. Some of us are in high-risk categories. Some of us live with and care for elderly and sick family and community members. The inequities in living conditions and access to health care are deep and multi-generational. It’s just not appropriate for anyone to dictate, or critique, someone else’s response to this virus.


Perhaps some of the best outcomes that we can hope for, once we get on the other side of this pandemic, are, first, that we grieve our losses and the shortcomings of our public responses to the virus, including the lack of national leadership on issues related to the pandemic. Then, perhaps we will learn more about our vulnerabilities as a society, and enact policies and programs, build community networks and organizations, to better equalize the risks we face and support the most vulnerable in our society. Perhaps we can improve our “immune health” collectively, not just individually.


A first step for this moment is to VOTE in the November 2020 election. :-)